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Title   국소적 식도암에서 선행 화학요법과 방사선 병행치료후 수술을 하는 복합치료의 효과 - 중간 보고 - ( Effects of Concurrent Chemoradiotherapy Followed by Surgery in Locoreginal Cancer - preliminary report - )
Publicationinfo   1996 Jan; 028(04): 690-698.
Key_word   Preoperative chemoradiotherapy, Esophagectomy, Esophageal cancer
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Abstract   Prognosis of locoregional esophageal cancer treated with conventional surgery or radiotherapy alone has been very poor. In order to improve outcome and determine the efficacy of a combined modality therapy, this prospective study was performed. Between May 1993 and April l995, 44 patients with locoregional esophageal cancer were entered this study. They were treated with 2 courses of 5-FU(DI-5, D30-33) and cisplatin (Dl, D29) plus 48Gy radiation therapy over 4 weeks. 44 patients completed the preoperative reatment. A transhiatal esophagectomy was planned 3~4 weeks after chemoradiotherapy. Clinical response were reevaluable in 43 patients after treatment: 34 patients showed improvement, 5 patients showed stable, 4 patients showed progression. One patient was died of sepsis 1 week after completion of chemotherapy. l8 patients underwent operation after chemoradiation and 9 patients showed complete pathologic response. Grade 3,4 leukopenia and thrombocytopenia were observed in 21% and 7%, respectively. Esophagitis and vomiting were moderate to severe in 43% patients. Median follow-up duration was 7.5months(2-21M), the median survival was not reached. In conclusion, this intensive combined therapy is promising modality with regards to relatively high pathologic complete response rate. Further randomized Jarge scaled study was warrented
저 자   장윤혜(Yun Hae Chang),김성배(Sung Bae Kim),김상희(Sang HeeKim),최종수(Jong SU Choi),장대영(Dae Young Chang),이제환(Je Whan Lee),김상위(Sang We Kim),서철원(Cheolwon Suh),이규형(Kyon Hung Lee),이정신(Jung Shin Lee),김우건(Woo Gyun Kim),송호영(Ho Young Song),장혜숙(Hye Sook Chang),김종훈(Hong Hoon K